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ADAMTS13 PROTEIN
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DeCS
Descriptor
English
:
ADAMTS13 Protein
Descriptor
Spanish
:
Proteína ADAMTS13
Descriptor
Portuguese
:
Proteína ADAMTS13
Synonyms
English
:
A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
ADAMTS-13 Protein
ADAMTS13 Protease
vWF-Cleaving Protease
von Willebrand Factor-Cleaving Protease
ADAMTS 13 Protein
vWF Cleaving Protease
von Willebrand Factor Cleaving Protease
Tree Number:
D08.811.277.656.675.374.102.500.813
D09.400.430.500.500.813
D12.776.395.033.500.813
D12.776.860.300.085.813
Definition
English
:
An ADAMTS protease that contains eight
thrombospondin
(TS) motifs. It cleaves
VON WILLEBRAND FACTOR
to
control
vWF-mediated
THROMBOSIS
.
Mutations
in the ADAMTS13 gene have been identified in familial cases of
PURPURA
, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with
MYOCARDIAL INFARCTION
;
BRAIN ISCHEMIA
;
PRE-ECLAMPSIA
; and
MALARIA.
History Note
English
:
2017
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
56487
Unique Identifier:
D000071120
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS